Vaspin inhibits kallikrein 7 by serpin mechanism

KLK 7 ( kallikrein - related peptidase 7 )

Five variant mRNA transcripts have been identi-fied. These include transcripts using different 5' untranslated regions (UTRs) including exon 1 deletions, and transcripts using different 3'UTR regions. Using rapid amplification of cDNA ends (RACE) different KLK7 5'UTR sequences were identified from RNA extracted from pancreas, skin and ovarian cells, suggesting the expression of tissue specific ...

Amiloride Inhibits Mammalian Renal Kallikrein

A B S T R A C T Renal kallikrein is localized in luminal plasma membranes of the mammalian distal nephron and gains access to urine from this site. Its activity is regulated, in part, by aldosterone. These facts led us to study the effects of amiloride, a drug known to inhibit sodium reabsorption and potassium secretion at this site, on kallikrein activity. Amiloride inhibited the esterolytic a...

Inhibits Autoimmune Inflammation in Type Enhanced Anti-Serpin Antibody Activity

The mechanism by which glyceraldehyde inhibits glycolysis.

In 1929 Mendel (1) discovered that nL-glyceraldehyde in concentrations of 1O-3 M almost completely inhibited the anaerobic formation of lactic acid from glucose by rat sarcoma. Glyceraldehyde, even in much higher concentrations, did not appreciably affect the respiration of normal liver, kidney, and brain, or of malignant cells. Somewhat later Mendel, Bauch, and Strelitz (2) found that the addi...

Diflunisal inhibits prestin by chloride-dependent mechanism

The motor protein prestin is a member of the SLC26 family of anion antiporters and is essential to the electromotility of cochlear outer hair cells and for hearing. The only direct inhibitor of electromotility and the associated charge transfer is salicylate, possibly through direct interaction with an anion-binding site on prestin. In a screen to identify other inhibitors of prestin activity, ...